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dc.contributor.authorLugaajju, A
dc.contributor.authorReddy, S. B.
dc.contributor.authorWahlgren, M
dc.contributor.authorKironde, Fred
dc.contributor.authorPersson, K. E. M.
dc.date.accessioned2017-05-17T09:23:41Z
dc.date.available2017-05-17T09:23:41Z
dc.date.issued2017
dc.identifier.citationLugaajju, A...et al. (2017) Development of Plasmodium falciparum specific naïve, atypical, memory and plasma B cells during infancy and in adults in an endemic area. Malaria Journal.en_US
dc.identifier.urihttp://hdl.handle.net/20.500.12309/182
dc.description.abstractBackground: B-cells are essential in immunity against malaria, but which sub-sets of B-cells specifically recognize Plasmodium falciparum and when they appear is still largely unknown. Results: Using the flow cytometry technique for detection of P. falciparum specific (Pf+) B-cells, this study for the first time measured the development of Pf+ B cell (CD19+) phenotypes in Ugandan babies from birth up to nine months, and in their mothers. The babies showed increases in Pf+ IgG memory B-cells (MBCs), atypical MBCs, and plasma cells/blasts over time, but the proportion of these cells were still lower than in the mothers who displayed stable levels (5, 18, and 3%, respectively). Pf+ non-IgG+ MBCs and naïve B-cells binding to P. falciparum antigens were higher in the babies compared to the mothers (12 and 50%). In ELISA there was an increase in IgG and IgM antibodies over time in babies, and stable levels in mothers. At baby delivery, multigravidae mothers had a higher proportion of Pf+ IgG MBCs and less Pf+ naïve B-cells than primigravidae mothers. Conclusions: In newborns, naïve B-cells are a major player in recognizing P. falciparum. In adults, the high proportion of Pf+ atypical MBCs suggests a major role for these cells. Both in infants and adults, non-IgG+ MBCs were higher than IgG MBCs, indicating that these cells deserve more focus in future.en_US
dc.language.isoenen_US
dc.publisherBio Med Centralen_US
dc.subjectPlasmodium falciparumen_US
dc.subjectB-cellsen_US
dc.subjectMalariaen_US
dc.subjectImmunityen_US
dc.subjectMemoryen_US
dc.subjectAtypicalen_US
dc.titleDevelopment of Plasmodium falciparum specific naïve, atypical, memory and plasma B cells during infancy and in adults in an endemic areaen_US
dc.typeArticleen_US


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