Faculty of Health Sciences

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Browsing Faculty of Health Sciences by Author "Adewoye, S.O"

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    Evaluation of Proximate Composition and Phytochemical analysis of Terminalia Schimperiana Root.
    (Academia, 2017) Awotunde, O.S; Adewoye, S.O; Hawumba, J; Nuwamanya, E
    The Proximate composition and phytochemical characteristics were determined for Terminalia schimperiana root. The root was collected and extracted with water and the phytochemical screening was carried out using the standard procedures. Phytochemical screening of the aqueous extract of Terminalia schimperiana root revealed the presence of alkaloids, saponins, Phenolics, anthocyanin and Tannins. The Proximate analysis results obtained showed the amount of crude protein, crude fat and total carbohydrates to be 6.31±0.75, 4.64±0.82 and 17.79 ±0.53 respectively of the sample while the percentage of crude fiber, ash and moisture content in the root sample were 32.72 ±0.59, 0.35±0.12 and 10.35±0.18 respectively. The present study revealed that the plant contain many nutrients and phytochemicals that may be responsible for some medicinal and aphrodisiac properties.
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    Histopathological and Organ-Body Weight Ratio Alterations Induced by Oral Administration of AQUEOUS Extract of Terminaliaschmiperiana Root in Some Selected Organs in Male WISTAR Rats
    (International Journal of Advanced Research in Science, Engineering and Technology, 2017) Awotunde, O.S; Adewoye, S.O; Hawumba, J.; Alinaitwe, Lordrick
    The toxic potential of the crude aqueous extract was investigated by evaluating the body-weight ratioand histologic changes of the liver, kidney and testes after oral administration of the extractto rats at various doses (1000, 2000, 3000mg/kg) daily for21 days. On the first, seventh and twenty first day,the rats werehumanely sacrificed under chloroform anesthesiaand the selected organs excised. There was no significant difference (P<0.05) in the kidney-body weight ratio when compared with the control group, while the administration at all the doses resulted in significant (P<0.05) reduction in liver-body weight ratio.An increase in testes-body weight ratio was also observed at the dose of 2000mg/kg. Histopathologicexamination of the liver, kidney and testes after 21 days of administration of the extract revealed mild changes in the architecture of the tissues.The male wistar rats did not show any treatment-related defects nor overt clinical signs of toxicity neither did the extract produce any sedative effect.